BIOLOGY 154 Lecture Notes - Lecture 6: Antigen, Macrophage

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15 Sep 2016
Department
5ImmuneSystem
ZikaVirus
inBrazil,appearedthatZikalinkedtomicrocephaly
normalmicedonotgetsickfromZika
scientistslookingtoseeifZikahasmutatedinanyway
placentacellsactasnormallineofdefense
studyhowthesecellsreacttoZika
tostudytherelationshipbetweenZikaandbirthdefects
AdaptiveImmuneSystem
HumoralResponse(inblood)
1. BCells
a. specificantibodyforaspecificBCell
b. pathogenbindstotheBcell
c. generateantibodieswhenactivated
i. disablesthepathogen
ii. onlyactivatedforthingsthatarefloatingaround
iii. MemoryBCells
iv. getactivatedfasterthenexttimeitisexposedtopathogen
d. EffectorBCells
i. produceantibodiestoattackthespecificantigenonthepathogen
CellMediatedResponse
1. TCells
a. HelperTCells
i. specificTcellreceptorondifferenthelperTcells
1. specificfordifferentMHCII
ii. becomesactivatedwhenitbindstoadendriticcellthathasanMHCIIcomplex
onitssurface
1. proliferatesmanycopiesofHelperTCells
a. effectorHelperTCells
i. releasescytokineswhicharelikealarmbells
ii. cytokinestellBcellstodividemoreoften
b. memoryHelperTCells
b. KillerTCells
i. directlyattackinfiltratedcells
ii. strengthofTkillercellsresponseaffectshealthoutcome
1. longtermsurvivorsofHIVhaverobustTkillercellresponses
iii. touchacellandblowitup
1. terminatecancercellsandcellsinfectedbyavirusorbacterium
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