BIOLOGY 202L Lecture Notes - Lecture 12: Allele Frequency, Haplotype, Genetic Diversity
21 Jan 2016
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Two populations: one is fixed for one, one is fixed for the other allele random mating = Nucleotide diversity: measure of diversity given dna sequences. Consider: how does allele frequency change in a generation: selection from zygotes to adults via survival. Favorability refers to preference of one phenotype over the other with regards to survivability. Frequency of rare allele is 0. 01, so in a population of 500 diploids (1000 alleles) . Therefore, the allele hides in the heterozygotes much more often than it is seen in homozygote; kept alive k = mu. = 2n(mu) x (1/2n) rate of neutral evolution = (probability of fixation)(total alleles present) x (rate of fixation) 1/2n = rate of fixation of new mutations per generation. 2n = number alleles present, n = number of individuals (mu) = probability of mutation per generation. More new mutations, less chance any are fixed. Genotype frequencies change, not necessarily allelic frequencies inbreeding, random mating, etc.
