BIOLOGY 202L Lecture Notes - Lecture 25: Genetic Linkage, Heritability, Statistical Power
21 Jan 2016
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Document Summary
Look for natural selection in regions of decreased variability with the principle of selective. See that human evolution hasn"t undergone many recent selective sweeps more like rapid evolution a long time ago in one allele and spread out through populations via migration routes. Possible that many genes affecting one trait and that natural selection only changes each of these genes by a little to produce an overall larger effect on the trait that could explain adaptation. Another explanation is human culture and technology solving these problems. Evolution currently on traits that affect reproduction especially for people in developed countries. Qtl mapping: association between genotype (homo and hetero) and average value of the trait. Tracing how a snp change correlates with a phenotypic change. Segregated out in a backcross see many snps. Crossing-over/recombination scrambles association between genotype and phenotype. Examines genetic variants between individuals to determine if any variant is associated with a trait.
