GENOME 222FS Lecture Notes - Lecture 20: Allele, Citric Acid Cycle, Axin1
11 Feb 2019
School
Department
Course
Professor
Document Summary
Epigenetic factors (readers, writers, erasers) require intermediary energy metabolites as co-factors. Nutrient availability regulation of gene expression homeostasis. Defects in metabolism or metabolic diseases affect epigenetic factors and vice versa. S-adenosylmethionine (sam): product of 1 carbon (1c) metabolism, depends on zinc, methionine, vitamin b factors (choline, folate) Diet and metabolites induce changes in histone modifications and gene expression. Gene loci that can be epigenetically modified. Originally described by randy jirtle"s lab (at duke) Across genetically identical cells/animals, many phenotypes can be observed. Agouti- gene that encodes a signaling molecule that causes melanocytes to produce. Maternal bpa exposure shifts offspring coat color distribution toward yellow (agouti) How might the human epigenome be affected by diet and nutrition. Famine from november 1944 through spring 1945. 20k people died, others became very malnourished. Long-term effects of dietary restriction/malnourishment can be studied. Excellent record-keeping studied birth weight of babies conceived during. Exposure to famine in early versus later gestation had later outcomes.
