NEUROSCI 101 Lecture Notes - Lecture 12: Basal Ganglia, European Route E20

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17 May 2016
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Interval Timing Discussion
Lewis et al. (2003), Interval timing in mice does not rely upon the circadian pacemaker
1. With a successfully lesioned SCN, you expect arrhythmic running.
2. Mice’s activity was tracked using an actogram to measure periods of inactivity and
activity.
3. Mice had to reproduce the interval using a peak procedure. Lesions to the SCN had no
effect in the produced interval.
4. One thing the researchers could have improved in the experiment was to guarantee
that all mice had complete SCN lesions, since some with partial lesions did not
display arrhythmic running.
Within-subjects study to compare mice before and after the lesion
Researchers examined reaction time for interval testing 2 days before the lesion and 10
days after the lesion
Duke labs: 300 trials over the course of 2 days
Lewis: Gaussian models, the shorter the duration, the narrower the spread of the graph
Other parts of the brain can compensate for SCN damage or basal ganglia damage
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