BIOL 1100 Lecture 25: Lecture 25
Document Summary
Epigenetic inheritance - patterns of inheritance that is not due to differences in gene sequences. Histone code hypothesis: precise patterns of chemical modifications of histones, varies from one cell type to another, contain information that influences gene expression. Mediator - middle man first binds to activator protein and binds basal transcription factors. Gene transcription is initiated by transcription factors that help recruit rna polymerase to the promoter (core promoter sequence - tata box are bound by tbp) Activator: binds to enhancer to activate/turn on genes, binds when dna is opened (chromatin is relaxed) Repressor: binds to silencer to repress/turn off genes. Improving (far away from dna promoter); doesn"t code for any protein. Activator (dna binding protein)binds to enhancers (dna sequence) Repressors bind to silencer sequences to turn off genes. Gene expression requires: opening up chromatin, binding of transcriptional regulators/factors, recruiting rna polymerase to the start site.