BIOL 141 Lecture Notes - Lecture 7: Nucleoside Triphosphate, Atp Hydrolysis, Ribonucleotide
11 Mar 2018
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Alternately, exergonic is release of energy; can be spontaneous. *breaking down of molecules to simple monomers (bonds hold potential energy) *can be broken down for energy & provides materials for growing chain. *hydrolytic reaction (add water) => adds h to first bound phosphate, other. 2 additional phosphate groups can be added to ribonucleotide => nucleotide triphosphate (activated nucleotide) component. Atp is not the only form of an activated nucleotide, just most common b/c of cellular respiration. Release of energy associated w/ atp hydrolysis drives dna polymerization. Polymerization results in nucleic acids w/ a sugar-phosphate backbone (negatively-charged) Nitrogenous bases are amphipathic => mostly non-polar, but outward faces have polar motifs. Rosalind franklin: x-ray diffraction --- 3 repeated distances: 0. 34 nm, 3. 4 nm, 2. 0 nm. Dna is stabilized by hydrogen bonds and hydrophobic interactions in the interior. Negatively-charged sugar-phosphate backbone of dna is hydrophilic => dna water-soluble. Rna unique for information holding and catalytic function (relatively short-term lifespan)
