NBB 301 Lecture Notes - Lecture 14: Reverberatory Furnace, Calmodulin, Hebbian Theory

• School: Emory University
• Department: Neuroscience & Behavioral Sci
• Course: NBB 301
• Professor: Frenzel Kristen

Document Summary

Synaptic plasticity - ltd: defn: activity dependent reduction in the efficacy of a synapse, focusing on hippocampus (both ltp and ltd, stimulating schaffer collaterals with 1-hz stimulus, glutamate releases --> unblocks nmda --> ca release. Induced by strong stimulation (usually 100 hz tetanus) Requires a fast, large increase in postsynaptic [ca++] Induced by weak, ongoing stimulation (1hz for >= 1 minutes) Requires a slow and small increase in postsynaptic [ca++] Receiving input from climbing fiber and parallel fibers: when both stimulated at the same time --> can depress parallel fibers. G-protein coupled signaling --> activates phospholipase c --> create dag (-->activate. Pkc --> phosphorylate ampa receptors---> internalize the ampa receptors) and. Ip3(receptors in the er which hold ca out of cytoplasm- --> more ca is released) ----> downregulation of ampa receptors. *make existing ampa receptors more responsive (ie pass more current) **increase # ampa-rs (phosphorylation can affect the insertion of ampa-r;