PSB 3002 Lecture Notes - Lecture 22: Amygdala, Transcranial Magnetic Stimulation, Synaptic Plasticity

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23 Mar 2018
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Long-term effects of stress are harmful to overall health, including brain health. Prenatal stress results in long-lasting deficits in learning and memory by affecting fetal hippocampal development. The effect of long-- ter(cid:373) e(cid:454)posure to glucocorticoids/stress had what kind of effect on the ca1 pyramidal cells of the monkey hippocampus? (hint: slide 32, lecture 23) acute (short-term) stress can affect brain functions such as learning. Exposure of rats to a cat had 3 key effects on hormone levels, synaptic plasticity, and learning. Long-term exposure to glucocorticoids destroys neurons located in field ca1 of hippocampal formation. Hormone destroys neurons by decreasing entry of glucose and decreasing reuptake of glutamate. Prenatal stress can cause long-lasting malfunctions in learning and memory. Severe stress appears to cause brain damage in humans. Brain degeneration in ct scans of people subjected to torture. More mild forms of stress early in life also appear to affect brain development.

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