PSB 3002 Lecture Notes - Lecture 24: Amyloid Precursor Protein Secretase, Neuroglia, Cytoskeleton
Document Summary
Hereditary disorder, caused by dominant gene on chromosome 4. Defect identified as repeated sequence of bases that code for amino acid glutamine (collaborative research group, 1993) Abnormal huntingtin is cause of huntington"s disease; protein interacts with growth factor during development. Abnormal huntingtin builds up in neurons and causes cell death. Causes progressive memory loss, motor deficits, and eventual death. --produces severe degeneration of hippocampus and many cortical areas. --results in a form of dementia (loss of cognitive abilities including perception, memory, verbal skills, and judgment) The brains of alzheimer"s patients show severe degeneration of the hippocampus and related cortical areas. Under the microscope, what 2 types of abnormal structures are commonly observed in. App needs to be clipped by secretase e(cid:374)z(cid:455)(cid:373)e to ge(cid:374)e(cid:396)ate -amyloid protein. Normal brains have 90-95% sho(cid:396)t - amyloid protein. Alzheimer brains have as little as 60% short form (or too much long form) Pet scans comparing healthy and alzheimer"s patients found accumulation of what protein in.