BSC 1086C Lecture Notes - Lecture 6: Bone Marrow, Lymph Node, Immunity (Medical)

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20 Feb 2017

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Originate in red bone marrow: b cells mature in the red bone marrow, t cells mature in the thymus. When mature, they have: immunocompetence; ability to recognize and bind to a specific antigen, self-tolerance- unresponsive to self antigens. Na ve (unexposed) b and t cells are exported to lymph nodes, spleen, and other lymphoid organs. T cells mature in the thymus under negative and positive selection pressures: positive selection- selects t cells capable of recognizing self-mhc proteins, negative selection- prompts apoptosis of t cells that bind to self- antigens displayed by self-mhc. Lymphocytes make up to a billion different types of antigen receptors: coded for by ~25,000 genes, gene segments are shuffled by somatic recombination. Genes determine which foreign substances the immune system will recognize and resist. Only antigens that match an existing antigen receptor will be recognized and start an immune response. Dendritic cells in connective tissues and epidermis. Macrophages in connective tissues and lymphoid organs.

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Question 4 (9 points):

To study T cell development, and self-restriction of T cells, you decide to perform some experiments. You obtain four mouse strains: B, B-MCC, K, and K-MCC. B strain mice express MHC molecules of the b haplotype (e.g. H-2K^b, H-2D^b, I-A^b) while K mice express MHC of the k haplotypes (e.g. H-2K^k, H-2D^k, I-A^k). The strains are otherwise genetically identical. B-MCC and K-MCC are identical to the B and K strains (respectively) excepts that contain a transgene encoding the antigen Moth Cytochrome which is not present in normal mice. MCC is produced as both a secreted and cytoplasmic protein and it is expressed by dendritic cells and thymic epithelial cells. You lethally irradiate groups of mice from all four strains and perform all possible bone marrow transfers among the mice. In other words, the BM of each strain is transplanted into mice of each strain, producing 16 different combinations of donor BM and recipient strain. You now take T cells from the lymph nodes of each of the 16 types of transplanted mice and test their ability to proliferate in response to MCC-presenting B cells that express only class II MHC molecule, I-A^k. Fill out the chart below by indicated which mice will have T cells that respond. Use (+) to indicated proliferation and NR to indicate a lack of proliferation. In addition, for the mice labelled a-e give a brief explanation for your answer. Include the mechanism of T cell selection experienced in thymus (positive selection, negative selection, or neglect) and the cells involved in selection (thymic epithelial cels, BM-derived APCs, or both).

Table (4 points, 0.25 points per box)

Recipient Strain Â®

BM Donor	B	B-MCC	K	K-MCC
B			c.
B-MCC			d.
K	a.	b.	e.
K-MCC

1 point for each explanation

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BSC 1086C Lecture Notes - Lecture 6: Bone Marrow, Lymph Node, Immunity (Medical)

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