MCB 2000 Lecture Notes - Lecture 14: Reticular Connective Tissue, Mononuclear Phagocyte System, Lymphatic Vessel
Document Summary
Innate, nonspecific: 1st line of defense (anatomical and physiological barriers, 2nd line of defense (cellular and chemical systems, acquired, specific, 3rd line of defense, naturally acquires, active (infection, passive (maternal antibodies, artificially acquired, active (vaccination, passive (immune system. Mechanism of phagocytosis: 5 phases of phagocytosis, chemotaxis - phagocytes are attracted by, microbial products, damaged tissue cells, the plasma membrane of the phagocyte attaches to the microbe and identifies it as nonself . Ingestion: a phagocyte extends the pseudopods that engulf the microbe. Antimicrobial substances: the body produces antimicrobial substances: Interferon alpha and beta (produced by ;lymphocytes, macrophages, fibroblasts) Interferon gamma (produced by t-cells: the complement system, serum proteins that contribute to destruction of microbes. Interferons: proteins that interfere with viral multiplication, produced and released by a virus - infected cell, this triggers the cell to produce antiviral proteins (avps, other effects.
