PCB 4232 Lecture Notes - Lecture 7: Reverse Transcriptase, Retrovirus, Aids
18 Dec 2016
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Testing is mandatory for = blood, organ, sperm donors. Until 2010 it was mandatory for all us emigrants and refugees. Blacks are the ones that tested voluntarily the most. Because of mutations, hiv develops resistance to antivirals. Azt azidothymidine reverse transcriptase inhibitor (nrti) Azt binds instead of thymidine and blocks reverse transcriptase. Protease inhibitors (end in vir . except for the one that starts in r(this is integrase inhibitor)) Haart highly active retroviral therapy -> combinations of atleast 3 anti retroviral drugs. Current drugs can only achieve functional cure because of cellular reservoirs and anatomical sites not accessible to arv (brain) Gene editing technologies zinc finger nucleases bind motifs linked to restriction nuclease fok1. Crispr/cas 9 system uses short complementary rna bound to cas9 nuclease. This targets hiv provirus / chemokine co receptor. Drug acceptance: lab tests + animal models, clinical trials (3 steps, fda approval.
