PCB 2061 Lecture Notes - Lecture 11: Rifampicin, Deoxyribonuclease I, Heparin

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3 Aug 2017
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H-t-h 1. 1; blocks the exit pore of rna. Some nif genes have dual promoters, which can be turned on either by sigma 70 or sigma 54. Sigma 54 is very unusual since it can bind promoter in the absence of rnap core. Sigma 54 activates the constitutive promoter of nitrogen starvation gene glna. Sigma looses affinity for the promoter dna and rnap core, and pressure of growing rna chain dislodges sigma from the rna exit pore. By binding alternative specialized sigma subunits, which recognize different cis-element sequences and various configurations of the promoter. Listed below are sigma subdomains followed by its function. By sliding, hopping, or transfer between very at-rich sequences located along dna helix w/ By recognition of specific dna cis-elements at position -10 and the equivalent of -35, as well as promoter configuration (distance between cis-elements) Heparin is negatively charged; acts as a competitor to knock off any rnap that is not in a stable open complex formation.

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