BSC-1005 Lecture Notes - Chimera (Genetics), Preimplantation Genetic Diagnosis, Adult Stem Cell
Document Summary
February 21, 2014: human germline engineering: genetically modified humans, gene therapy, this is the process of using dna as a therapeutic (in contrast to drug therapy, in general, a mutated gene must be fixed by either. Replacing the mutated gene with a normal gene: also, kill cancer cells using genes, dna vaccines genes to combat infectious diseases, somatic cell gene therapy [type 1] vs. reproductive (aka germline) gene therapy. Somatic cells: cells derived from the basic germ layers of the body (endoderm, mesoderm, ectoderm) that do not pass their genetic information to the next generation. Genetically identical ipscs are generated from the patient. Adult stem cells are isolated and propagated in the laboratory. This only works for adult stem cells that can be isolated, however. Gene therapy often exploits viruses to deliver genes to cell nuclei. Development of gene delivery vehicles that do not rely on viruses. New ways to destroy, introduce, or repair genes: slide with picture of scissors.
