PSB-2000 Lecture Notes - Lecture 10: Stroke, Intracerebral Hemorrhage, Brain Ischemia
Document Summary
Stroke is the third leading cause of death in the u. s. and the most common cause of adult disability. Ischemic stroke (blockage: thrombus: forms and blocks at same location. Blood clot, tumor cells, plaque, etc: embolus: forms elsewhere travels through vasculature until it gets stuck, arteriosclerosis: wall of blood vessels thicken, usually due to fat deposits. Hemorrhagic stroke (bleeding: ruptured blood vessel, aneurysm: balloon-like dilation in the wall of a blood vessel, which makes a stroke more likely. Blood (oxygen)-deprived neurons become overactive & release glutamate. Usually benign; surgically removable: most (~80%) brain tumors are infiltrating. Malignant; difficult to remove or destroy: stroke: a sudden-onset disruption in blood flow that causes brain damage 2 types. Edema (swelling) also causes slowing of sodium-potassium pump further depolarization: net effe(cid:272)t is (cid:862)h(cid:455)pere(cid:454)(cid:272)ita(cid:271)ilit(cid:455)(cid:863) Also disruption of bbb: traumatic brain injuries. 2 types: epidural between skull and dura, subdural between dura and brain, most fatalities are from excitotoxicity.
