BIOL 222 Lecture Notes - Lecture 3: The Double Helix, Maurice Wilkins, Linus Pauling
9 Sep 2016
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Lecture #3: structure of dna and rna - the double helix. Group hw due on monday the 12th. Practice problems: c=g, a=t, n-glycosidic bond attaches the base to the sugar. Always at 1" carbon: dna glycosylases can cleave n-glycosidic bonds. Helps x mutations: nucleoside = just a nucleus and a sugar. Linus pauling: proteins can have secondary structures and form alpha helices, ball-and-stick models, noticed that there was intramolecular hydrogen bonding that created secondary structures. Rosalind franklin & maurice wilkins: x-ray diffraction. X-ray beam shone through dna bers, and the x-rays diffracted by dna formed an image: franklin"s results suggested. Helical structure, 10 base pairs per turn. Watson and crick: used pauling"s, chargaff"s, and franklin"s data and put it all together, hinted that the way pairing occurred in dna was a hint towards the way dna was copied. Dna strands: antiparallel and complementary, right-handed (clock-wise turning, major and minor grooves.
