HSCI-102 Lecture Notes - Lecture 7: Vasomotor Center, Natriuretic Peptide, Medulla Oblongata
7 Feb 2019
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Autoregulation: vasodilators and vasoconstrictors, at tissue level, sphincter control in capillary beds, neural regulation, cardiovascular centers i) ii) iii) Chemoreceptor reflex: hormonal regulation, renin-angiotensin 2 - aldosterone system i) intermediate/long term effects, atrial natriuretic peptide (anp) i) ii) Vasomotion: at rest precapillary sphincters rhythmically open and close (12 min: vasodilators: decreased o2, increased co2, lactate, excess ions, inflammation, increased temperature, vasoconstrictors: thromboxanes, protaglandins. Cardiovascular control center (medulla oblongata: vasomotor center: directs vasomotor responses in blood vessels, cardiac centers, cardioacceleratory center: increases co via sns, cardioinhibitory center: decreases co via pns. Supramedullary regulation: hypothalamus and cortex connect with the cardiovascular control center to alter its activity (during exercise, emotional responses, etc) Decrease in bp is key stimulus for activation of sympathetic nervous system. Norepinephrine will stimulate arteriolar vasoconstriction in most organs. Arteriolar vasoconstriction will help to increase tpr (total peripheral resistance) in order to maintain blood pressure. Vasodilation can also be stimulated directly to brain and skeletal muscles by no.
