BIOL 1511 Lecture Notes - Lecture 20: Stop Codon, Pyrimidine, Purine
Document Summary
Intragenic mutation suppression occurs in same gene. Induced mutation chemical agents are introduced into your environment causing mutation; actual base substitution is caused by environment that it is placed in: epigenetic mutations. 5-bromouracil analog of thymine while keto form base pairs with adenine, the enol form base pairs with guanine. Specific mispairing: some mutagens do not incorporate into dna but they alter bases so that specific mispairing occur, ex. Ethylmethanesulfate (ems) adds alkyl groups to various positions on all 4 bases looks like adenine even though it is guanine. Intercalating agents: planar molecules that can slip themselves in (intercalative) between the stacked nitrogen bases at core of dna helix can cause insertions or deletions of single base pairs. Base damage: uv light, lesions that unite pyrimidine residues in same strand cause replications block because dna pol will not proceed past base that cannot specify complementary partner by hydrogen binding will cause further mutations during repair.
