BIOL 2344 Lecture Notes - Lecture 21: Homologous Recombination, Sister Chromatids, Immunogenetics
Document Summary
Recombination ~ involves chromosomes breaking and rejoining to from new combinations. Site specific recombination ~ occurs when non- homologous dna segments are recombined at specific sites. 12 diversity domains (between v and j domains: v(d)j recombination = diversity in domains, recombination signal sequence ~ found at end of every v domain and beginning of every. J domain: rag1 and rag2 are proteins which initiate recombination event. Imprecise end joining and somatic hypermutations: 1. Connection phase is catalyzed by nhej proteins, not entirely precise, so a few nucleotides can be added or lost at junction between variable and joining domains: 2. Somatic hypermutation ~ antibody genes undergo high rate of mutation in somatic cells.