BIOL 4570 Lecture Notes - Lecture 22: Antigenic Variation, Antigen, Apoptosis
Document Summary
Chapter 13 : antigenic variation, stealth, subversion of immune response, suppression of immune response. Antibodies provoked or created in response to 1st strain and ineffective in 2nd strain. 2nd strain can damage and infect host until host responds again. Antibodies created in previous year are not fully effective. Brain is protected site unavailable to major parts of immune system. Immunodeficiency diseases: rare, patterns, diagnosis from symptoms, prognosis after diagnosis, treatment or cure. Scid (severe combined immunodeficiency diseases) humoral and cellular arms are affected. Hsc clp pro b cell pre b cell immature b cell (bone marrow all) b cells (periphery) Hsc (bone marrow) clp (bone marrow) pro nk (periphery) or pro t cell (thymus onward) pre. T cell double pos t cell cd4 or cd8 t cell (periphery) Hyper igm syndrome defect in cd40/l interaction. Classical defects can lead to immune complex disease antibody to apoptotic cell fragments; absence of path, antigen: antibody complexes can be deposited in tissues.
