KH 3650 Lecture Notes - Lecture 2: Bicarbonate Buffer System, Hemoglobin, Exosphere
26 Apr 2016
School
Department
Course
Professor
Document Summary
Acid: h+ donor (ex: hcl h+ + cl- Base: h+ acceptor (ex: hco3- + h+ h2c03. Concept of ph ph = - log [h+] Scale from 0 (acid) to 14 (alkaline), 7 is neutral. Physiological ph limits: alkalosis to 8. 0 overstimulation of cns convulsions, tetany, acidosis to 6. 8 depression of cns coma, resting ph arterial = ~ 7. 4. Metabolic acidosis high intensity exercise, uncontrolled diabetes (ketones) Effect of exercise on ph: atp hydrolysis small release of h, creatine phosphate breakdown small uptake of h, oxidative phosphorylation co2 + h2o h2co3- + h, anaerobic glycolysis lactate production, metabolic acidosis. Effect of high intensity exercise on ph: muscle: lactate can increase to ~35 mmol/l, ph can decrease to. ~6. 4 6. 8: blood: lactate can increase to ~20-25 mmol/l, ph can decrease to. ~6. 8: gradient from muscle to blood: lactate transported across sarcolemma to blood. Increase muscle lactate concentration: decrease muscle ph decrease key enzyme activity myosin.
