KH 3650 Lecture Notes - Lecture 5: Bicarbonate, Cori Cycle, Gluconeogenesis

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26 Apr 2016
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Starts with carbohydrates (glucose or glycogen), eventually will convert to pyruvate or lactate. Food -> mouth, small intestine, liver, blood, muscle glycogen. If oxygen is available, pyruvate enters the mitochondria for further breakdown. Rate limiting enzyme: substance 1 (enzyme a rate limiting, substance 2 (enzyme b, substance 3 (enzyme c) Pyruvic acid -----(ldh)-- lactic acid: nad+ (oxidized state, nadh (reduced state) Metabolic acidosis: glu gly la [ lactate] ph. Effect of lactate and h+ ion on the actomyosin complex. Reduces the force the muscle is going to make. 2 atp"s via glucose, 3 atp"s via glycogen: anaerobic. Predominant energy system in high intensity exercise (ex: sustained, repeated sprints). Oxidation of lactate by the liver krebs cycle. The lactate shuttle shuttled from fast twitch fiber. Lactate removal uptake/oxidation by heart, liver, kidneys, etc. Treadmill time trial 10 km, half marathon: measurements time, vo2, hr, blood samples.

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