NURS 2060 Lecture Notes - Lecture 5: Degranulation, Kinin, Lectin
Document Summary
Inflammation and natural barriers (skin, epithelial membranes) = nonspecific/innate responses: goals of inflammation: mobilize large #"s of neutrophils, monocytes, and plasma proteins to the area (this protects the host, limit the extent of injury, and promotes rapid healing) Describe the main cell types in acute and chronic inflammation: mast cells, endothelial cells, platelets, phagocytes (neutrophils, eosinophils, monocytes, macrophages), natural killer (nk) cells, and lymphocytes. Describe the sequence of events in acute inflammation: local manifestations: vasodilation , capillary permeability, migration of wbcs to injury site. Plasma protein cascade systems: highly interactive (hageman factor; factor xii: clotting factor, tightly regulated (turns off inflamm. response) Kininases (degrades bradykinin: complement system: activation may destroy pathogens directly/may activate or collaborate with other components of inflamm. response ; triggered by 3 different pathways: Alternative (activated by gram-negative bacteria and fungal cell wall polysaccharides) Prevents spread of infection, traps microorganisms and foreign bodies at site of inflamm. for removal.
