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Lecture 1

BMS 212 Lecture Notes - Lecture 1: Microbial Ecology, Germ Theory Of Disease, Syphilis

6 pages38 viewsFall 2016

Biomedical Sciences
Course Code
BMS 212
Aaron Baxter

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BMS 212 - Exam 1 lectures
I. The Importance of Microbiology - INTRODUCTION
We thought we had reached the end of infectious diseases because:
1. Antibiotics were being developed
2. We thought we had classified every source
3. Public health was better
4. Vaccines were being developed
5. Smallpox had recently been eliminated we got arrogant and thought we could
eliminate the others just as easily
But…in the 1980s:
1. New diseases arose HIV, West Nile, etc
2. Diseases became resistant to antibiotics
3. Not all diseases have a vaccine each time one is developed the diseases mutates
4. Longer lives longer exposure, weakening immune system
5. Lifestyle or genetic diseases might have viral or bacterial components
II. The Scope of Microbiology
The study of living things that are too small to be seen without magnification.
Microbes Impact and/or presence
1. They are ubiquitous found everywhere
2. They are important in biological processes i.e. cows require certain bacteria
to digest grass
3. Recycling they help in the nitrogen cycle
Major groups of microorganisms
6 major groups
1. Bacteria and archeaebacteria (bacteria that prefer extreme environments)
2. Fungi eukaryotes, not photosynthetic
3. Protozoa eukaryotes, most are not pathogens but those that are can cause big
4. Algae photosynthetic, none are true pathogens, these produce the bulk of the
world’s oxygen
5. Helminths parasites (worms, etc.), can be large enough to be visible
6. Viruses particles, not living organisms
III. History of Microbiology
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A. Early History *don’t need to know the dates – just names and contributions*
Robert Hooke 1665
- Built an early compound microscope
- Coined the term “cell”
- Formulated the concept that there are living, functional things that are too
small to see
Antoni van Leeuwenhoek 1674-1723
- Drew/recorded what he saw under his microscopes
- Described the “animalcules” that he saw in a series of letters to the Royal
Society of London
- Discovered the microbial world with his microscope
*animalcules: small animals*
His work led to many different branches of study
- Bacteriology bacteria
- Phycology algae
- Mycology fungi
- Protozoology protozoa
- Parasitology
- Virology viruses (not
developed until later)
B. The Golden Age of Microbiology (late 1800s- early 1900s)
Question #1: Biogenesis vs. abiogenesis
Biogenesis: “life comes from life”
Abiogenesis: “life comes from nothing” spontaneous generation
1. Franciso Redi (1688)
- Didn’t believe that decaying meat spontaneously formed flies
- Put meat in three jars one covered with paper, one with gauze, and one
- Discovered that when the decaying meat was isolated (sealed with paper) no
maggots appeared. The uncovered meat was infested, the one covered in
gauze had maggots on the gauze.
- Concluded the maggots came from flies that were drawn to the meat life
comes from life
2. John T. Needham - to be noted in your reading
- Boiled beef gravy and plant broth, then tightly sealed the flasks with cork
- Days later he examined them and found microbial life
- Concluded that spontaneous generation did exist because the boiling should
have killed anything living
3. Lazzaro Spallanzani to be noted in your reading
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