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Lecture 7

BMS 212 Lecture 7: Unit 1, Section 7- Viral Structure, Classification, and Growth of Viruses

3 Pages

Biomedical Sciences
Course Code
BMS 212
Aaron Baxter

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Viral Structure, Classification and Growth of Viruses Historical contributors: 1. Charles Chamberland- advanced the ability to create sterile items and developed bacterial filters and autoclaves 2. Beijerinck and Ivanowski- Used Chamberlands bacterial filters to establish the existence of the Tobacco Mosaic Virus – the virus fell through the filter - Called these entities Contagium Vivum Fluidium - Integral in the establishment of virology I. Viruses vs. Life Criteria for life: 1. Growth- the ability to increase in size 2. Reproduction- the ability to increase in number 3. Responsiveness- change in internal/external properties in response to the environment 4. Metabolism- taking in nutrients, reactions to create energy that’s stimulate growth *Viruses do not meet criteria 1 or 4, so they are defined as “particles”* II. Structure A. Size B. Structures in viruses 1. 3 general classifications of viruses 1. Icosahedron 2. Helical 3. Complex and 1. Naked 2. Enveloped 2. Common structure to all viruses a. Central core - Nucleic acid: o DNA or RNA o Single or double stranded o Circular or linear o Segmented or non-segmented - Small number of genes o i.e. humans have 30,000, hepatitis B has 4 - Function is very directed: replication of outer material and genetic material, regulation of the host, and packaging i. some viruses also carry a few very specific enzymes a. Polymerases: synthesize viral specific DNA or RNA b. Replicases: copy RNA c. Reverse transcriptase: convert RNA to DNA ii. other enzymes a. Outer Covering 1. Capsid i. nucleocapsid: the nucleic acid and capsid collectively ii. c
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