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Lecture 7

BMS 212 Lecture 7: Unit 1, Section 7- Viral Structure, Classification, and Growth of Viruses

3 Pages
89 Views
Fall 2016

Department
Biomedical Sciences
Course Code
BMS 212
Professor
Aaron Baxter
Lecture
7

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Viral Structure, Classification and Growth of Viruses
Historical contributors:
1. Charles Chamberland- advanced the ability to create sterile items and developed bacterial
filters and autoclaves
2. Beijerinck and Ivanowski- Used Chamberlands bacterial filters to establish the existence
of the Tobacco Mosaic Virus the virus fell through the filter
- Called these entities Contagium Vivum Fluidium
- Integral in the establishment of virology
I. Viruses vs. Life
Criteria for life:
1. Growth- the ability to increase in size
2. Reproduction- the ability to increase in number
3. Responsiveness- change in internal/external properties in response to the environment
4. Metabolism- taking in nutrients, reactions to create energy that’s stimulate growth
*Viruses do not meet criteria 1 or 4, so they are defined as “particles”*
II. Structure
A. Size
B. Structures in viruses
1. 3 general classifications of viruses
1. Icosahedron
2. Helical
3. Complex
and
1. Naked
2. Enveloped
2. Common structure to all viruses
a. Central core
- Nucleic acid:
o DNA or RNA
o Single or double stranded
o Circular or linear
o Segmented or non-segmented
- Small number of genes
o i.e. humans have 30,000, hepatitis B has 4
- Function is very directed: replication of outer material and genetic
material, regulation of the host, and packaging
i. some viruses also carry a few very specific enzymes
a. Polymerases: synthesize viral specific DNA or RNA
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Description
Viral Structure, Classification and Growth of Viruses Historical contributors: 1. Charles Chamberland- advanced the ability to create sterile items and developed bacterial filters and autoclaves 2. Beijerinck and Ivanowski- Used Chamberlands bacterial filters to establish the existence of the Tobacco Mosaic Virus – the virus fell through the filter - Called these entities Contagium Vivum Fluidium - Integral in the establishment of virology I. Viruses vs. Life Criteria for life: 1. Growth- the ability to increase in size 2. Reproduction- the ability to increase in number 3. Responsiveness- change in internal/external properties in response to the environment 4. Metabolism- taking in nutrients, reactions to create energy that’s stimulate growth *Viruses do not meet criteria 1 or 4, so they are defined as “particles”* II. Structure A. Size B. Structures in viruses 1. 3 general classifications of viruses 1. Icosahedron 2. Helical 3. Complex and 1. Naked 2. Enveloped 2. Common structure to all viruses a. Central core - Nucleic acid: o DNA or RNA o Single or double stranded o Circular or linear o Segmented or non-segmented - Small number of genes o i.e. humans have 30,000, hepatitis B has 4 - Function is very directed: replication of outer material and genetic material, regulation of the host, and packaging i. some viruses also carry a few very specific enzymes a. Polymerases: synthesize viral specific DNA or RNA b. Replicases: copy RNA c. Reverse transcriptase: convert RNA to DNA ii. other enzymes a. Outer Covering 1. Capsid i. nucleocapsid: the nucleic acid and capsid collectively ii. c
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