ANAT 2130 Lecture Notes - Lecture 6: Neural Plate, Diverticulum, Primitive Knot

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Earliest rearrangement of cells in vertebrate embryo. Establishes from epiblast, three primary germ layers: ectoderm, mesoderm, endoderm. Changes in cell shape cause rearrangements of existing cells. Changes in nearest neighbor relations cause tissue rearrangements. In primitive node, some epiblast cells invaginate to become mid-line mesoderm: this notochord extends cranially as primitive node regresses caudally. Lies along mid-line axis of body, along axis of bilateral symmetry, just deep to neural plate, between somites. Plays role in induction of neural plate in overlying ectoderm. Forms transient connective tissue rod beneath neural plate and between somites. Portion in vertebral bodies converted to bone. Portion in invertebrate discs persists in adult as nucleus pulposus. Serve as cushioning shock absorbers between vertebrae. Have a tough fibrous capsule called the annulus fibrosus, which binds adjacent vertebral bodies. Has gelatinous core called the nucleus pulposus. In ruptures disc, annulus fibrosus is torn and compression/pressure extrudes nucleus pulposus onto nerve roots, causing both sensory and motor deficits.

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