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Lecture 12

Lecture 12 – Structure of DNA.docx

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Department
Life Sciences
Course
Life Sciences 1a
Professor
Robert Lue
Semester
Fall

Description
Oct 10 – Structure of DNA ­ Delbruck teacher of James Watson, thought that there was something else out  there that explained genetics ­ Watson and Crick discovered structure of DNA ­ DNA strand has directional polarity  ▯asymmetric, doesn’t mean partial charges ­ Antiparallel strands  ­ Hydrogen bond length between the nitrogenous bases is identical ­ Watson discovered base pairing through matching cutouts ­ Proteins are irregular because of irregular sequence of amino acids ­ DNA embeds irregularity within regular structure  ▯irregular in the sense that base   pairs are irregular, each base pair is different, overall architecture, physical  structure of DNA is the same ­ A:T and G:C base pairs result in identical diameter of helix  ­ Rosalind Franklin used Xray diffraction “photo 51”  ­ Maltese cross revealed helix, missing layer line revealed helix is double,  reflection revealed 3.4 angstrom spacing of base pairs  ­ Despite repulsion from negative charge, double helix favored over single­stranded  DNA ­ However, the bonding is very favorable  ­ Hydrogen bonds not that important for stabili
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