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Lecture 15

Lecture 15 – Translation.docx

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Department
Life Sciences
Course Code
Life Sciences 1a
Professor
Robert Lue

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Oct 22 – Translation ­ 61 codons specifiy amino acids, other three are stop codons ­ each tRNA molecule charged by specific amino acid, recognizes particular codon ­ le chatelier’s drives reaction forward  ­ each amino acid has its own synthetase, multiple tRNAs for each amino acid ­ ­2 or 3 kcal/mol is around Keq of 100  ­ tRNA would make mistake by incorporating valine instead of isoleucine 1% of  the time ­ synthetase has to proofread  ­ isoleucine can’t slip in editing site because extra methyl group makes it too big ­ ribosome made of large and small subunits  ▯RNA and proteins ­ mRNA translated in 5’ to 3’ direction ­ protein synthesized in NH2 t
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