BIOL 1414 Lecture Notes - Lecture 13: Transfer Rna, Prokaryotic Large Ribosomal Subunit, Glucan
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For bacteria this is going to be inhibitors of pg synthesis. This is a common target and it is a good one because eukaryoes do not have peptidoglycan. Hence, these drugs ae very non-toxic except for people that are allergic to them. These drugs usually inhibit the formation of a chemical bond between the sugar subunits. Do new peptidoglycan cannot be made and growing cells die. Penicillins: the (cid:271) la(cid:272)ta(cid:373)s (cid:271)e(cid:272)ause all pe(cid:374)i(cid:272)illi(cid:374)s have (cid:862)a (cid:271)eta la(cid:272)ta(cid:373) ri(cid:374)g. (cid:863) this ri(cid:374)g (cid:272)a(cid:374) be destroyed by enzmes called beta lactamases which destroys the penicillin. Alternative penicillins have been developed that resist b-lactamases such as methicillin. Other alternative penicillins can resist stomach acid so they are given by mouth (amoxicillin) but the first one pencillin g, and it was acid sensitive. Vancomycin: is a large molecule, almost like a peptide. It is given iv to people in the hospital with few alternatives. The crossbridges cannot form in the presence of cycloserine.
