BIOL10800 Lecture Notes - Lecture 6: Central Nervous System, Cytochrome P450, Adverse Drug Reaction
25 Oct 2016
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Cell body that has a long tail called made up of axons with a space between itself and a target cell: space is called a synapse (area is called the terminal) Cell body: receives inputs, integrates, initiates response. Axons move inputs received by cell body to the target cell. Reaction chemical made from cell latches onto receptor of target cell. Brain and spinal cord: receive information and store it. Outside spinal cord and brain information is carried into or out of cns. Drugs can be divided into various classification schemes: structural- small molecule (nicotine), peptide (insulin), lipid (steroids, i. e. estrogen, prototype- cholinergic, adrenergic, serotonergic, etc , receptor action- agonist, antagonist, physiological action- diuretic. For a drug to be useful it must (adme: absorbed: oral, cutaneous, parenteral, distributed: volume of distribution, lipid soluble or not, metabolized: activating pro-drugs, terminating drug action, excreted: mechanism or termination, elimination of breakdown products.
