AN S 345 Lecture Notes - Lecture 23: Brown Adipose Tissue, Adipose Tissue, Adipocyte
21 Mar 2017
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Document Summary
Hormonal control importance/function of adipose tissue is adipocyte development. Storage of cholesterol, vitamin d and e. Adipose expansion occurs via hyperplasia and hypertrophy. The committed preadipocyte (adipoblast) maintains the capacity for growth. Has to withdraw from the cell cycle before adipose conversion. Acquisition of the adipocyte phenotype characterized by chronological changes in the expression of numerous genes. The appearance of early, intermediate and late mrna/protein markers and triglyceride accumulation. These changes primarily, but not solely, take place at the transcription level. Pre-adipocyte factor-1 (pref-1) is found in pre-adipocytes but is absent in adipocytes. Pref-1 is made as a transmembrane protein but is cleaved to generate biologically active soluble form. After growth arrest pre-adipocytes must receive an appropriate combination of mitotic and adipogenic signals to continue through the subsequent differentiation steps. Growth arrested cells undergo at least one round of dna replication and cell doubling. Increased production of prostacyclin (pgi2) enhanced by glucocorticoids.
