BIOL-K - Biology BIOL-K 338 Lecture 4: Innate Immunity Notes
7 Feb 2017
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Cytotoxic t-cells and helper t-cells, dth 9delayed type hypersensitivity), direct cell contact: non-specific. Inborn, non-adaptive defense mechanisms (phagocytosis: always present and ready, rapid response, first line of defense, weak protection, non-specific (can damage host cells: collateral from inflammation) Acquired immunity (specific: develops in response to infection (recruited, very powerful, essential in vertebrate, does not damage host cells/tissues, slow (week or so after infection develops) Innate immune system: pamps: only on microbes (not in humans) Pathogen associated molecular pattern: damps: damaged/death associated molecular pattern (necrotic or apoptotic cells, self-nonself: ignore own cells and attack damaged cells/pathogens. Perfect in innate, good in adaptive: memory responses: none in innate memory, major cell types. Adaptive: lymphocytes, antigen presenting cells, mhc i cells and mhc ii professional. Infectious diseases occur when initial innate responses fail to contain pathogen. First line of defense (defense at epithelial surface)
