BIOL-K 338 Lecture 5: 5-6. Antigen-Antibody Notes

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Antigen/Antibody
Lecture 5-6
Antigen
o Molecule that can bind to B or T cell
o Molecule that elicits specific immune response (IMMUNOGEN)
o Can activate B or T cells
Antigenic
o Molecule capable of binding B or T cell receptor
o Molecule capable of inducing immune response (IMMUNOGENIC)
Antibody
o Molecule attached to or secreted by B cells that bind to an antigen
o All antibodies on 1 B cell have same specificities/conformations
Clonal Selection
o Make copies of antibody (proliferation) that binds to present antigen
Epitope/ Antigenic Determinant
o Region of antigen that binds to t-cell receptor or b-cell receptor (site of antibody attachment)
o ALWAYS on antigen
Immunodominant Epitope
o Epitope where most antibodies or greatest t-cell response is experienced in given immunization
Which epitope of antigen may vary from person to person
o Epitope spreading: recognition of other epitopes as immune response progresses and dominant
is dealt with
PRR’s Patter Reogitio Reeptors
o Fixed specificity (limited number)
o Not rapidly adaptable
Many b cells produce antibodies, but an antigen will bind to an antibody conformation
o PRP: pattern recognition protein
Free floating, not on surface of cell
Antibody Response
o Must be acquired
o Only after encounter w/ pathogen will immunes system expand
Acquired response after presentation of infection
Differentiation=Specialization
B cell capable of binding is proliferated (clonal selection)
Antibody removes due to complement activation, phagocytosis, opsonization, ADCC, or
neutralization
o Effector: physically does something (plasma, majority of B cells, secretes antibody)
Memory Cells: waiting for next encounter to react faster
Plasma Cells: antibody acts as opsinizing factor, make more likely to activate
phagocytosis and will cause inflammation
o Antibody can neutralize toxins, block from attaching to cells
Neutralize pathogen by opsinizing (stop binding)
o Antibody Dependent Cell-Mediated CytoToxicity (ADCC)
Antibody coats antigen and calls in cells to kill pathogen with toxins
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