AS.280.335 Lecture Notes - Lecture 2: Astrocyte, Tight Junction, Biotransformation
13 Sep 2016
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Document Summary
Not only do exposures occur and are there effects from such exposures, but there are also susceptibility factors: ability to metabolize biological agents/sensitivity to certain chemicals, socioeconomic status. Biomarkers of internal dose are detectable and measurable elements, whose presence at the molecular, cellular, and organismal levels is indicative of environmental exposure. Design primary (prevent exposure) and secondary (mitigate adverse effects of exposure) interventions from the study of toxicology. Principle 1 of toxicology: toxic action of a substance is a consequence of the physical/chemical interaction of the active form of that substance with a molecular target within the living organism (i. e. cells) Principle ii: magnitude of toxic effect is a function of the concentration of altered molecular targets; related to the concentration of the active form of the toxicant at the site where the molecular targets are located. Exposure occurs through ingestion (gastrointestinal tract), inhalation (lungs), or dermal (skin)
