BSCI 10001 Lecture Notes - Lecture 6: Integral Membrane Protein, Lipid Bilayer, Cystic Fibrosis
28 Apr 2019
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Document Summary
Membranes, part 2: now lets talk about the proteins found in biological membranes. In 1972, singer & nicholson, combined new evidence and a better understanding of membrane protein structure and properties to propose the fluid mosaic model for the structure of biological membranes. Singer & nicholson proposed that a hydrophobic sequence of amino acids would fold into an alpha helix to traverse the lipid bilayer: In a previous edition of your textbook (2nd edition) the structure of the transmembrane segment of an integral membrane protein was over-simplified In more recent editions this error has been corrected: Glycophorin a (the protein we just looked at) is a single pass) membrane protein; other membrane proteins are multi-pass proteins: X-ray crystallographic studies have amply confirmed that singer & nicholson were correct in their prediction of the structure of membrane proteins. But before these data came in, other experiments strongly supported the fluid mosaic model.
