BIOL 150 Lecture Notes - Lecture 17: Citric Acid Cycle, Oxidative Phosphorylation, Succinic Acid

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15 Mar 2018
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Biol 150 principles of molecular & cellular biology. The citric acid cycle, nadh and fadh2 and electron. We again went through the reactions by which acetyl-coa is fully oxidized to co2 in the mitochondrial matrix, through the reactions of the citric acid cycle. Surprisingly, the first step is link the 2 acetyl-group carbons in acetylcoa to the 4-carbon compound oxaloacetate to produce the 6-carbon compound citric acid, while regenerating the coenzyme a needed to react with pyruvate. After citric acid is made, it is then (rearranged slightly and) oxidized through 2 reactions in which the carbon molecule passes its electrons to the electron carrier nad+ to make. In each of these reactions, a carbon molecule is lost in the form of co2. In the second of these reactions, the remaining 4-carbon compound is linked to coenzymea (similar with what we saw with pyruvate).

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