JAPAN 1 Lecture Notes - Lecture 2: Synaptic Pruning, Limbic System, Axon Guidance

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Prenatal development: brain tissue growth, more a structural development: zygote: days 0-14, from conception to implantation on uterine wall, embryo: weeks 2-8, differentiation of most organs and body systems, fetus: week 8-birth, growth in size. Ectoderm: the outer cellular layer of the developing fetus, giving rise to the skin and the nervous system. Neural groove: the groove between neural folds in the developing embryo. Neural tube: develops out of neural groove, an embryonic structure with subdivisions that correspond to the future forebrain, midbrain and hindbrain. Interior of neural tube becomes the fluid filled cerebral-ventricles of the brain. +8 weeks: rudimentary beginning of body organs, head is half the size of the embryo. + 1 week: embryo shows three distinct cell layers (ecto-, meso-, Neural plate ->neural grove ->neural tube: neurogenesis/proliferation: differentiation of neural tube, production of nerve cells. Cells that give rise to neurons begin as a single layer of cells along inner surface of neuronal tube.

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