MATH 190 Lecture Notes - Lecture 5: Voxel, Pattern Matching, Frontal Lobe
Document Summary
Task 2: gogtay, n. , & thompson, p. m. (2010). Implications for typical development and vulnerability to psychopathology. Earlier studies using lobar volumes of specific anatomical regions. Specific anatomical regions showed how different lobes of the brain matured at different rates. With the advent of more sophisticated brain mapping methods, it became possible to chart the dynamic trajectory of cortical maturation using detailed 3d and 4d (dynamic) models, showing spreading waves of changes evolving through the cortex. This led to a variety of time-lapse films revealing characteristic deviations from normal development in schizophrenia, bipolar illness, and even in siblings at genetic risk for these disorders. We describe how these methods have helped clarify how cortical development relates to cognitive performance, functional recovery or decline in illness and ongoing myelination processes. Most major neuropsychiatric disorders are now thought to arise out of deviations from normal brain development, suggesting a neurodevelopmental basis for these disorders.
