BIOE-324 Lecture Notes - Lecture 7: Artificial Skin, Tissue Engineering, Copolymer
21 Feb 2019
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Document Summary
Hydrogels: contact lenses, drug delivery tissue engineering scaffold artificial skin , water swollen, cross-linked polymers. Covalent bond/association bond (h-bond or vdw interations)/crystallites: homopolymer, copolymer, multipolymer, interpenetrating polymer, neutral, anionic, cationic, ampholytic, amophorous, semi-crystalline, complexation structure, e. g: polyhema (contact lens) Cross-linking density: water content controlled by: Smart polymer hydrogels: ph sensitive acid or basic side chains: poly(acrylamide), poly(acrylic acid), pmaa, temperature sensitive: pnipam, complexing hyrdogels: poly(maag-eg) Advantages and disadvantages of natural materials: similar structure to macromolecules in biological environment. Biodegradable by naturally occurring enzymes: more complex structure than synthetic polymers. Elaborate to handle: special process to extrude at room t. Natural materials: mostly multi-functional: providing stiffness, strength, elasticity, resilience, toughness, and thermal protection, mostly hybrid or composite. Group 1: building blocks: proteins: keratin, elastin, resilin, abductin, glycoprotein and proteoglycans: collagen, polysaccharides: Structural: cellulose (plant), lignin (plant), chitin (exoskeleton: minerals. Passive: connective tissues (blood vessel, tendon, ligament, cartilage, hoof, horn, hair, tortoise shell: g3: mineralized tissue.
