BISC 464 Lecture Notes - Lecture 12: Angina Pectoris, Cirrhosis, Portal Hypertension
7 Nov 2017
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Document Summary
50% of all deaths in the us are due to cardiovascular disease. Right and left branches - left anterior descending artery- 50% of infarcts. Hits the septum, where the conduction mechanisms are. Thrombotic stroke- occlusion and infarct (artery intact- cva) Bleeding stroke- htn or congenital defect causing the artery to burst (hemorrhaging artery) Atheroma- primary lesion in small or large arteries. Starts with endothelial cell damage- an happen from htp, hlp. Surface where there is no endothelial cells is very thrombogenic. fibrin formation brings platelets to the area, which then degranulate. Smooth muscle cells respond to platelet growth factors (pdgf) released on degranulation, become hyperplastic (activated) or turn into foam cells, filled with cholesterol. Activated macrophages become foam cells, put out c(cid:455)toki(cid:374)es, attract (cid:373)ore cells of i(cid:374)fla(cid:373)(cid:373)atio(cid:374) . When it bursts, it is highly thrombogenic and clots again on top of it, making it larger and larger.
