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BIOL 1201 (700)
Lecture 1

BIOL 1201 Lecture Notes - Lecture 1: Phosphodiesterase, Aroma Compound, Phenelzine


Department
Biological Sciences
Course Code
BIOL 1201
Professor
E.Wischusen
Lecture
1

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!!
Cell$Signaling!
Direct!Contact:!
-Local!
Paracrine!and!synaptic!signals!
-Distant!
Hormonal!signals!(endocrine!system)!
!
!!

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When!a!platelet!contacts!a!damaged!blood!vessel,!it!is!stimulated!to!release!Thromboxane!A2.!
Thromboxane!A2,!in!turn!stimulates!vascular!spasm!and!attracts!additional!platelets!to!the!injured!site.!In!
this!example!thromboxane!A2!is!acting!as:!
1. Direct!contact!signal!molecule!
2. Local!signal!molecule!
3. Distant!signal!molecule!
!!
Stages$of$Cell$Signaling!
-Reception!
-Transduction!
-Response!
!!
Reception!

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Based!on!your!understanding!of!membrane!permeability,!the!signal!molecules!(ligands)!binding!to!
cytoplasmic!receptors!are?!
1. Polar!molecules!
2. Non-Polar!molecules!
3. Could!be!both!
Assuming!there!are!100!different!cells!signaling!compounds!in!your!body.!What!is!the!minimum!number!of!
receptors!that!your!body!needs!to!make?!
100!receptors!
!!
Signal$Transduction!
Examples:!
G-Protein!
Tyrosine!Kinase!
Ion-gated!Channel!
!!
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