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Lecture 20

BIOL 1201 Lecture 20: Chromosomes and GeneticsPremium

Biological Sciences
Course Code
BIOL 1201
Moroney, James

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BIOL 1201- Lecture 20- Chromosomes and Genetics
Chromomosomes and genes
Mendel did not have a physical mechanism to explain inheritance
Thomas Hunt Morgan (U.S.) hypothesized genetic information was carried by
Morgan tested this hypothesis using a simple genetic model, the fruit fly
The fruit fly (Drosophila melanogaster) as a genetic model:
o2 week life cycle, 100’s of offspring
o2n = 8
oEasily mutagenized; genetic variants
Morgan found a mutation in eye color
F1: all females have red eyes and all males have white eyes
F2: ½ the males had red eyes and ½ the males had white eyes – The Females all
had red eyes
Fly Crosses
Trait named for mutation, normal or wild type (WT); designated with +
Red-eye color allele is w+; white is w
Since red/white eye color is on the X chromosome; female genotypes: w+w+,
w+w, ww, male genotypes: w+y, wy
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