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Lecture 22

BIOL 1201 Lecture Notes - Lecture 22: Viral Envelope, Capsid, GlycoproteinPremium


Department
Biological Sciences
Course Code
BIOL 1201
Professor
Moroney, James
Lecture
22

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Biol 1201- Lecture 22- Viruses and Genomes
Viruses
Pages 381-390
Concepts 19.1 and 19.2
Figures: 18.2, 19.3, 19.4, 19.6, 19.7, 19.8
We will do only the sections listed in the study guide from now on
Structure
Genome (DNA or RNA)
Protein shell - capsid
Envelope (membrane)
Envelope with Glycoprotein
Variations in viral genome
Double-stranded DNA (dsDNA)
Single-stranded DNA (ssDNA)
Double-stranded RNA (dsDNA)
Single-stranded RNA (ssRNA)
DNA/RNA has to go into cell for successful infection
Genome has to be duplicated
Proteins are made from viral messages
Viral Reproduction (Lytic growth)
Infection of host cells
Infected cell synthesizes viral genome and protein (capsid)
Synthesis of other viral components
Assembly of viral particles
Host cell lysis releases particles
Viral Reproduction (Lysogenic growth)
Infection of host cells
Viral DNA integrates into host DNA
Every time the cell divides the virus also reproduces!
Once you get chicken pox, you have the virus forever as a variatoin of your own
cells. Can give you shingles.
Rhabdovirus: some viruses are specific for a few hosts. Rabies can effect
multiple mammals.
Reverse transcriptase: protein common in RNA viruses. Some viruses go RNA
then copied to DNA(reverse transcriptase) in host cell then back to RNA or
mRNA
HIV (human immunodeficiency virus) components
Genome – ssRNA (with reverse transcriptase)
Capsid protein
Viral envelope with glycoprotein
HIV Infection – bodily fluid transfer
Virus infects cells with certain cell surface protein (immuno defense cells)
Immuno defense fends off virus
Defense cells in lymph system are attacked and depleted over time
Acquired immunodeficiency syndrome (AIDS) –death by opportunistic infection
Flu virus evolves every year or two. Comes from Asis- because of combination of
human, pig, and dog flu sequences.
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