Class Notes (1,100,000)
US (460,000)
LSU (7,000)
BIOL (1,000)
BIOL 1201 (700)
Lecture 23

BIOL 1201 Lecture Notes - Lecture 23: G Protein–Coupled Receptor, Signal Transduction, HomeostasisPremium


Department
Biological Sciences
Course Code
BIOL 1201
Professor
Moroney, James
Lecture
23

This preview shows half of the first page. to view the full 2 pages of the document.
BIOL1201Lecture23CellSignalingandHomeostasis
CellSignaling
● Chapter11
● Pages206218plusfigure11.16
● Concepts11.1,11.2and11.3
SignalTransduction
● Acellreceivesanumberofexternalsignals
● Signalsfromneighboringcells
● Signalsfromdistantcells
● Howthecelldetectsandrespondstothesesignalsisaimportantareaofcurrent
research
SignalReceptors
● Gproteincoupledreceptors(membraneproteins)
● Tyrosinekinasereceptors(membraneproteinswithkinaseactivity)
● Ionchannelreceptors:(gaterespondstosignalinmembraneproteins)
● Intracellularreceptors
SignalTransduction
● Specificitydependsonreceptor
● Initiatedbysignalreceptorcomplex
● Ofteninvolvesproteinphosphorylation
o ProteinKinases–transferphosphatefromATPtoprotein
o Proteinphosphatases–removephosphatefromprotein
● “Signal”amplificationbypathway
● Ofteninvolvesproteinphosphorylation
o Proteinkinases–transferphosphatefromATPtoprotein
o Proteinphosphatases–removephosphatefromprotein
● “Signal”amplifiedbypathway
● Signaltransduction:sensesandrespondstothatsignal
● Somecellsdon’thavereceptorsandthereforedon’trespond
● Thecellsliningintestines,responseisdifferentthanskeletalcells
● Thingstoknow:Primary,SecondaryCyclicpsecondprotein,Gprotein
**CLICKERQUESTIONS**
● Whatisapremotor?ADNAsegmentthatbindsRNApolymerase(DNAsequencethat
bindRNApolymerase,wheretranscriptionbegins)
● Whatisanoperator?ADNAsegmentthatbindstoarepressor(notaprotein)
● InlyticgrowthAvirusinfectsabacterialcell,makesnewvirusandlysesthecell
● InlysogenicgrowthAvirusinfectsabacterialcellanditsdnaintegratesintothehost
DNA
● ReversetranscriptaseMakesDNAusingRNAasguide
Homeostasis
● Chapter45
concepts45.1,45.2partof45.4 
● Pages974984,991
PhysiologicalRegulation
● HomeostasisThesteadystatephysiologicalconditionofthebody
● Controlledbynegativefeedbackloops
● Physiologicalconditionvaries,changesbeyond“limit”
You're Reading a Preview

Unlock to view full version

Subscribers Only