BIOL 4190 Lecture Notes - Lecture 1: Tomato Bushy Stunt Virus, X-Ray Crystallography, Electron Microscope
Document Summary
Birth of virology: adolph mayer inoculated plants w tmv and saw agent was soluble and could not be grown in culture. Ivanowsky filtered agent through bacterial free filters; thought they were cracked; suggest agent was small bacterium or toxin: beijerinck found agent could only reproduce in host and was not inactivated by alcohol; father of virology. Chemical nature: stanley crystallized tmv was largely protein, bawden and pirie crystallized tomato bushy stunt virus concluded viruses were nucleoproteins (bc had p) Dna or rna which is enclosed in protective protein coats. Slide 42: why viruses can only reproduce themselves in living cells. Tiny creatures (although they do vary in size as seen with an em) Compact genomes of dna or rna intracellular parasites. Ld50: dose that is lethal for 50% of inoculation. Multiply only in living organisms: list all supporting evidence for the notion that viruses are a form of life. Virion: complete infectious viral particle; gene delivery system.
