ENVS 1126 Lecture Notes - Lecture 24: Xeroderma Pigmentosum, Pyrimidine Dimer, Pyrene
23 Nov 2016
School
Department
Course
Professor
Document Summary
What is a mutation: a mutation is a permanent, heritable change in the dna sequence of a chromosome, which leads to a change or loss of its normal function. A lesion is a change in the dna sequence. If it is not repaired, then it becomes a mutation: mutation rates in various organisms. Exposure to ultraviolet light can cause dna damage in the form of thymine dimers, which lead to kinks in the dna. Xeroderma pigmentosum: defect in the multi-enzyme process by which c and t dimers (many of which are caused by uv light) are repaired, xp patients can rapidly develop multiple skin cancers if exposed to sunlight. Dna adducts and smoking: dna adducts: a complex between carcinogenic substances and dna, example: Benzo(a)pyrene (bp) found in cigarette smoke and charbroiled (grilled) foods. Iarc (international agency for research on cancer): examples of agents classified as.
