PSYC 2000 Lecture Notes - Lecture 12: Allosteric Regulation, Chronic Pancreatitis, Competitive Inhibition
Document Summary
Other proteins regulate getting rid of protein. If something binds to the protein the protein changes in shape - reaction catalyzed. Substrate - enzymatically catalyzed steps - end product. If end product keeps building up, the end product can come back and inhibit enzyme 1 to stop production. Enzyme has active site which will fit a specific substrate into it. Allosteric regulator site has allosteric regulator molecule come bind to it and the enzyme"s active site changes shape to block substrates from fitting into active site - enzyme is now considered to be off. Negative allosteric regulation (because it turned enzyme off) If it binds somewhere other than allosteric regulator site, it wont affect the active site. Differently shaped substrate can fit into active site - for this reaction it is labeled as positive allosteric regulation because a specific substrate can fit. Regulator does not bind to active site. Can change dna sequence to create different protein.
