BIO 325 Lecture Notes - Lecture 3: Chemotaxis, Endothelium, Viscosity
Document Summary
Inflammation: if cells are injured or killed and a host survives, inflammatory response always occurs. Results in: blocking, neutralizes, and eliminates infectious agents and toxins, demolishes necrotic tissue, establishes conditions necessary for repair of damaged tissue, enhances immune response. Immune cells brought to the areas exit circulation to attack invaders at site of injury: lymphatic vessels help drain off exudate by opening pores in lymphatics wider. Sometimes bad because it drains infection and toxic agents into other tissue: lymph nodes contain many immune cells to attack invading pathogens, lymphatics may become infected. Cellular aspects of inflammation ( 2-4 hours to 10 hours: normal blood flow in vessels has formed elements moving along in laminar flow. Laminar flow: moving in center of vessel but not bumping along walls. Leucocytes marginate: move to vessel walls and cling on sticky venules inner lining. Diapedesis: leucocytes use amoebid movement to move out of capillaries through open pores of separated capillary wall cell into interstitium.
