MBI 111 Lecture 1: MBI 111 Notes 1_27
11 May 2017
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Document Summary
Pathogen microbe whose relationship with host is parasitic and results in infection and disease. Pathogenicity an organisms potential to cause infectious disease. Opportunistic pathogen: associated with compromised immune systems. Entry, establishment, ad multiplication of microbes within a host: finding a portal of entry, attaching firmly, surviving host defenses. Virulence level of pathogenicity (how bad is the bug?) Virulence factor any characteristic that assists a microbe cause a disease. Surface molecules on bacteria attach to complementary binding sites/receptors on host cell surfaces. Different bacteria have different binders and receptors. Bacterial virulence factors for evasion of host defenses. Resistance to engulfment by immune system cells: ex. Antigenic variation: surface molecules area changing over time, pathogen stays one step ahead of immune system. Certain bacteria live within host cells allowing evasion of immune attack. Bacterial virulence factors that directly damage the host organism.
